A new method of “genome editing” of the Nobel Prize in Chemistry

New method of genome editing, Nobel Prize in Chemistry October 7, 23:38

Two researchers from a German research institute and an American university who developed a new method of genome editing were selected for this year’s Nobel Prize in Chemistry. Research is also underway in Japan using this technology. It is the reaction of Japanese researchers.

Successful cultivation of madai with 1.2 times more body mass than usual

Professor Keitaro Ieto of University, who is conducting research using genome editing technology, which won the Nobel Prize in Chemistry, said, When I first learned about genome editing technology, I wanted to use it immediately with such innovative technology. It was faster than I expected, but I thought I would win it someday.”

Professor Ieto and his group have successfully farmed red sea red seas, which have increased their body volume by 1.2 times more than usual using genome editing techniques, and are currently working on improving other fish such as tiger tigers. Professor Ieto said, “In the past, when we were trying to improve fish, it took 15 to 20 years to combine generations. It was shortened to about four years by using genome editing technology. The amount of food eaten by the madai who edited the genome is the same as that of a normal red soybean, but the amount of body increases.”

Professor Ieto and his friends said that they are conducting research aimed at the distribution of red sea red seas that have been improved by genome editing, and said, “The aquaculture industry in Japan continues to be flat, but if we use genome editing technology, we should be able to improve the breed of fish that can be farmed more efficiently. With this award, we would like to see the use of genome editing technology in Japan advance, and the aquaculture industry itself will become a vital opportunity.”

“The speed of breeding crops has increased dramatically.”

Professor Hiroshi E surface of the University of Tsukuba, who has been researching the breeding of tomatoes using genome editing technology, said, “This technology has dramatically increased the speed of breeding crops. I thought I’ll win the prize for many years, so I thought, ‘Finally.’ I think that the award has made genome editing technology recognized worldwide as one of the technologies useful to people.”

Professor Eman developed tomatoes containing many components that are said to lower blood pressure, and is proceeding with procedures for sales, saying, “In the agricultural field, we have been using mutations to improve varieties, so it is said that there is no problem in applying genome editing. There are some areas that need to be discussed in their respective fields, such as medical care and livestock, so I hope that this award will increase interest and make this technology more useful to people.”

“Utilization in agriculture is about maturity: Ethical issues in terms of medical care”

Masashi Furukawa, Research Officer at the Japan Science and Technology Agency, said, “In addition to being evaluated in terms of chemical reactions to gene sequences, it is thought that the use in agriculture has matured. On the other hand, in terms of medical care, research is progressing in cancer treatment, but ethical aspects have not been solved, and this is a problem. This award, which was awarded in a short period of eight years after the paper was published, reflects the high level of attention around the world.”

“The Risk of Genome Editing: A Mechanism for Firmly Assessing”

Tetsuya Ishii, a professor at Hokkaido University who specializes in bioethics, said, “I think this Nobel Prize was won in order to win it. However, it has been pointed out that genome editing technology has the risk of uninsinned genetic modifications. Since it has become a technology related to health, such as breeding food and its application to medical care, I think it is necessary to create a mechanism to firmly assess this risk in Japan or internationally. In addition, we should prohibit the use of genome editing techniques such as having been used in China to manipulate the genes of fertilized eggs to actually give birth to babies.”

“The big question is how far this technology will be applied to humans.”

Kazuto Kato, a professor at Osaka University’s Graduate School of Medicine who is well-knowledgeed about the ethical issues of life sciences and medicine, said that “there is no doubt that it is a revolutionary technology and a very useful technology” regarding genome editing methods that have been awarded the Nobel Prize in Chemistry. The idea of the world is that even to cure diseases, fertilized eggs should not be genome-edited and rewritten genes to be passed on from generation to generation. It is prohibited to conduct research in Japan, but there are no legal regulations, and I would like you to proceed with the study.”

Prof. Kato said that it is necessary for countries around the world to come together to create rules, and that “society as a whole needs to think about ethics, laws, etc. so that we can confidently advance research on technologies that are really useful.”

Shinya Yamanaka, Director, iPS Cell Research Institute, Kyoto University “Innovative Discovery”

Shinya Yamanaka, director of the iPS Cell Research Institute at Kyoto University, made a comment on Twitter about Jennifer Dowdona’s decision to win the Nobel Prize in Chemistry. Mr. Yamanaka and Mr. Dowdona both work as researchers at the Gladstone Institute in California, USA.

Mr. Yamanaka said, “Congratulations on the award, Dr. Daoudna. As a colleague of Gladstone Labs, I would like to thank you from the bottom of my heart. Genome editing technology using CRISPR-Cas9 is an epoch-making discovery not only in medicine but also in all life sciences, and I would like to express my sincere respect for its achievements.”

“Technology that revolutionized history”

Professor Ri Aiki of the Graduate School of Science at the University of Tokyo, who has been friends with Jennifer Dowdona and Emmanuel Charpantier, who have been awarded the Nobel Prize in Chemistry, and are researching treatments using genome editing techniques, said, “It’s a technology that revolutionized history by being able to rewrite the blueprints for any life activity. Since this technology came out into the world, the range of applications has expanded at an accelerated pace, and the impact on society has been large. That’s a big achievement.”

Professor Wetting said, “I myself am a rival, but they have been congratulating each other when their research has been successful. As a researcher in the same field, I am pleased with the award decision. We also want to continue our research to develop treatments for basic and intractable diseases so that we can save many people who are suffering.”

“The momentum to drive the genome editing industry”

Taku Yamamoto, president of the Japanese Society for Genome Editing and a professor at the Center for Genome Editing Innovation at Hiroshima University, said, “I thought there was no doubt that genome editing would win the Nobel Prize sooner or later. “We are very happy to receive the award because we have proven that we can edit genetic information more easily and efficiently than previous methods, and that we have made it available to all researchers.”

On top of that, as new treatments and food development using genome editing technology are progressing around the world, he said, “It is a technology that will significantly change our lives in the future, but Japan is behind the world in some aspects. I hope the Nobel Prize will give many young people an interest and give them the opportunity to promote the genome editing industry.”

On the other hand, Professor Yamamoto said, “It is not a situation where ethical issues such as the safety issue of how accurately genetic information can be rewritten and the possibility of creating a designer baby are completely under control. We know it’s a great technology, but we have to use it to solve these problems.”